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Lathyrus



Interactions

Lathyrus/Drug Interactions:
  • AnticoagulantsAnticoagulants: Both Lathyrus odoratus L. and Lathyrus silvestris L. contain lectins that nonspecifically agglutinated human erythrocytes in laboratory study, although D-mannose and D-glucose inhibited this hemagglutinating activity (14; 15).
  • Osteoporosis agentsOsteoporosis agents: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.

Lathyrus/Herb/Supplement Interactions:
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Both Lathyrus odoratus L. and Lathyrus silvestris L. contain lectins that nonspecifically agglutinated human erythrocytes in laboratory study, although D-mannose and D-glucose inhibited this hemagglutinating activity (14; 15).
  • CalciumCalcium: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • Osteoporosis agentsOsteoporosis agents: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • ZincZinc: According to one theory, adequate zinc intake may reduce the risk of toxicity due to chronically high doses of Lathyrus sativus seeds (9).

Lathyrus/Food Interactions:
  • CalciumCalcium: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • Zinc-containing foodsZinc-containing foods: According to one theory, adequate zinc intake may reduce the risk of toxicity due to chronically high doses of Lathyrus sativus seeds (9).

Lathyrus/Lab Interactions:
  • CalciumCalcium: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • Coagulation panelCoagulation panel: Both Lathyrus odoratus L. and Lathyrus silvestris L. contain lectins that nonspecifically agglutinated human erythrocytes in laboratory study, although D-mannose and D-glucose inhibited this hemagglutinating activity (14; 15).
  • UrinaryoxalateUrinaryoxalate: In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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