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Sea buckthorn (Hippophae rhamnoides)
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Sea buckthorn/Drug Interactions:- ACE inhibitorsACE inhibitors: Based on in vitro study, the total flavones of Hippophae rhamnoides may have an inhibitory effect on angiotensin-converting enzyme (ACE) activity and on angiotensin II formation (5).
- Angiotensin II receptor antagonist (A2R blockers)Angiotensin II receptor antagonist (A2R blockers): Based on in vitro study, the total flavones of Hippophae rhamnoides may have an inhibitory effect on angiotensin II formation (5).
- AntibioticsAntibiotics: Based on in vitro study using five clinical strains of Helicobacter pylori, sea buckthorn may have antibiotic properties (6).
- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Clinical and animal studies report conflicting data regarding sea buckthorn's ability to decrease platelet aggregation (7; 8; 30).
- Antidiabetic agentsAntidiabetic agents: In a randomized crossover study in 12 normolipidemic men, ingestion of sea buckthorn berry oil 5g daily for four weeks did not affect plasma glucose when compared with the fractionated coconut oil control(8). However, in healthy mice, flavonoids from sea buckthorn reduced serum glucose levels (22).
- Antilipemic agentsAntilipemic agents: Based on several clinical trials, sea buckthorn oil may not affect low-density lipoprotein levels, but may increase high-density lipoprotein levels (21; 8; 7; 22; 1; 15).
- Antineoplastic agentsAntineoplastic agents: Based on in vitro studies, extracts of sea buckthorn have shown dose- and time-dependent anticancer effects (11; 14; 15; 12; 10).
- Antiulcer agentsAntiulcer agents: Based on animal study, sea buckthorn oil may significantly reduce ulcer formation (41; 42). One case study indicates that sea buckthorn may have preventive effects on gastric ulcers (43).
- Cardiovascular agentsCardiovascular agents: Based on in vitro study, the total flavones of Hippophae rhamnoides may have an inhibitory effect on angiotensin-converting enzyme (ACE) activity and on angiotensin II formation (5).
- CisplatinCisplatin: Based on a mouse study, sea buckthorn juice may decrease the genotoxic effects of cisplatin on bone marrow and sperm cells (44).
- CyclophosphamideCyclophosphamide: Sea buckthorn oil may decrease the cytogenetic action of cyclophosphamide (31).
- Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Based on in vitro evidence, sea buckthorn may have hepatoprotective effects and may protect cytochrome P450 enzymes from damage (19).
- FarmorubicinFarmorubicin: Based on laboratory evidence, sea buckthorn oil may decrease the cytogenetic action of farmorubicin (31).
- Hepatotoxic agentsHepatotoxic agents: Based on in vitro evidence, sea buckthorn may have hepatoprotective effects and may protect cytochrome P450 enzymes from damage (19).
- ImmunosuppressantsImmunosuppressants: Based on animal and in vitro study, sea buckthorn may have immunomodulatory activity (23; 32).
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Sea buckthorn/Herb/Supplement Interactions:- AntibacterialsAntibacterials: Based on in vitro evidence, sea buckthorn may have antibiotic properties against Helicobacter pylori (6).
- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Clinical and animal studies report conflicting data regarding sea buckthorn's ability to decrease platelet aggregation (7; 8; 30).
- Antigout herbs and supplementsAntigout herbs and supplements: Based on human evidence, sea buckthorn may decrease serum C-reactive protein concentrations, a marker of inflammation (17).
- Anti inflammatory herbsAnti inflammatory herbs: In a clinical trial, a reductive effect on CRP, a marker of inflammation and a risk factor for cardiovascular diseases, was detected in response to treatment with sea buckthorn berries (17).
- AntilipemicsAntilipemics: Based on several clinical trials, sea buckthorn oil may not affect low-density lipoprotein levels, but may increase high-density lipoprotein levels (21; 8; 7; 1; 22; 15).
- AntineoplasticsAntineoplastics: Based on in vitro studies, extracts of sea buckthorn have shown dose- and time-dependent anticancer effects (11; 14; 15; 12; 10).
- AntioxidantsAntioxidants: The antioxidant activity of sea buckthorn is unclear. Based on one clinical study (7), several laboratory assays, and animal studies (10; 45; 46; 19; 47; 48; 27; 23), sea buckthorn has shown antioxidant activity; however, a clinical trial using a combination of oatmeal porridge and sea buckthorn flavonols found no effect on plasma antioxidant potential or the levels of oxidized low-density lipoprotein (21).
- Antiulcer herbs and supplementsAntiulcer herbs and supplements: Based on animal study, sea buckthorn oil may reduce ulcer formation (41; 42). One case study indicates that sea buckthorn may have preventive effects on gastric ulcers (43).
- Cardioavascular herbs and supplementsCardioavascular herbs and supplements: Based on in vitro study, the total flavones of Hippophae rhamnoides may have an inhibitory effect on angiotensin-converting enzyme (ACE) activity and on angiotensin II formation (5).
- Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Based on animal in vitro evidence, sea buckthorn may have hepatoprotective effects and may protect cytochrome P450 enzymes from damage (19).
- Hepatotoxic herbs and supplementsHepatotoxic herbs and supplements: Based on in vitro study using tissue and serum from rats with induced toxic lesions of the liver, sea buckthorn may have hepatoprotective effects and may protect cytochrome P450 enzymes from damage (19).
- HypoglycemicsHypoglycemics: In a randomized crossover study in 12 normolipidemic men, ingestion of sea buckthorn berry oil 5g daily for four weeks did not affect plasma glucose when compared with the fractionated coconut oil control (8). However, in healthy mice, flavonoids from sea buckthorn have reduced serum glucose levels (22).
- ImmunosuppressantsImmunosuppressants: Based on animal and in vitro study, sea buckthorn may have immunomodulatory activity (23; 32).
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Sea buckthorn/Food Interactions:- Insufficient available evidence.
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Sea buckthorn/Lab Interactions:- Blood culturesBlood cultures: Based on in vitro study using five clinical strains of Helicobacter pylori, sea buckthorn may have antibiotic properties (6).
- Blood pressureBlood pressure: Based on in vitro study, the total flavones of Hippophae rhamnoides may have an inhibitory effect on angiotensin-converting enzyme (ACE) activity and on angiotensin II formation (5).
- Coagulation panelCoagulation panel: Clinical and animal studies report conflicting data regarding sea buckthorn's ability to decrease platelet aggregation (7; 8; 30).
- C-reactive protein (CRP)C-reactive protein (CRP): Based on clinical study, sea buckthorn reduced C-reactive protein (CRP) concentrations (17).
- Glucose levels (serum)Glucose levels (serum): In a randomized crossover study in 12 normolipidemic men, ingestion of sea buckthorn berry oil 5g daily for four weeks did not affect plasma glucose when compared with the fractionated coconut oil control (8). However, in healthy mice, flavonoids from sea buckthorn reduced serum glucose levels (22)
- Helicobacter pyloritestsHelicobacter pyloritests: Based on in vitro study using five clinical strains of Helicobacter pylori, sea buckthorn may have antibiotic properties (6).
- Immune panelImmune panel: Based on animal study, sea buckthorn may increase macrophage counts (32). Based on animal and in vitro study, sea buckthorn may have immunomodulatory activity (23; 32).
- Lipid profileLipid profile: Based on several clinical trials, sea buckthorn oil may not affect low-density lipoprotein levels, but may increase high-density lipoprotein levels (21; 8; 7; 1; 22; 15).
- Liver function testsLiver function tests: In human study, sea buckthorn has been shown to reduce serum levels of laminin, hyaluronic acid, collagen types III and IV, and total bile acid, compared to the control group (37). In addition, the sea buckthorn treatment notably shortened the duration for normalization of aminotransferases.
- Serum angiotensin-converting enzyme testSerum angiotensin-converting enzyme test: Based on in vitro study, the total flavones of Hippophae rhamnoides may have an inhibitory effect on angiotensin-converting enzyme (ACE) activity and on angiotensin II formation (5).
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Sea buckthorn/Treatment Interactions:- Radiation therapyRadiation therapy: Based on mouse studies, sea buckthorn may enhance macrophage counts and reduce oxidative damage induced by radiation therapy (49; 32).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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