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Stevia(Stevia rebaudiana Bertoni)
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Stevia/Drug Interactions:- Antidiabetic agentsAntidiabetic agents: Based on human (4; 17) and animal (4; 17) evidence, stevioside and aqueous extracts of Stevia rebaudiana leaves may decrease glucose levels. Rebaudioside A, a glycoside found in stevia, has been found to stimulate the production and activity of insulin (1).
- AntihypertensivesAntihypertensives: Based on clinical observations in humans, stevioside may decrease systolic and diastolic blood pressure (14; 13). Several animal studies support this observation (33; 37; 15). However, consumption of rebaudioside A did not produce clinically important changes in blood pressure in healthy adults with normal and low-normal blood pressure (34).
- Anti inflammatory agentsAnti inflammatory agents: Based on animal study, stevia appears to have anti-inflammatory activity (38). The effects of concurrent use of anti-inflammatory agents and stevia are not clear.
- Antineoplastic agentsAntineoplastic agents: In an in vitro study, isosteviol, a constituent of stevia, prevented the growth of human cancer cells (32). The effects of concurrent use of antineoplastic agents and stevia are not clear.
- Antiviral agentsAntiviral agents: In vitro, hot water extracts from Stevia rebaudiana inhibited the replication of all four serotypes of human rotavirus (11). The effects of concurrent use of antiviral agents and stevia are not clear.
- Calcium channel blockersCalcium channel blockers: Based on animal evidence, stevioside may act as a calcium antagonist (18). In an animal study, verapamil (a calcium antagonist) tended to increase the renal and systemic effects of stevioside (18).
- DiureticsDiuretics: Stevioside is secreted by renal tubular epithelia and induces diuresis and natriuresis (39) in animals. Theoretically, concurrent use of stevia and diuretics may cause additive effects.
- Fertility agentsFertility agents: Traditionally, stevia is used by women in Paraguay to control fertility (2). Based on animal evidence, chronic administration (60 days) of a Stevia rebaudiana aqueous extract may decrease male fertility (20). However, in another animal study, high doses of stevioside did not appear to have an effect on growth and fertility of both sexes (25). The effects of concurrent use of fertility agents and stevia are not clear.
- Sodium monoketocholate (MKC)Sodium monoketocholate (MKC): Combined pretreatment with stevia and sodium monoketocholate yielded lower values of glycemia in mice compared with that measured after treatment with stevia alone (40).
- VasodilatorsVasodilators: Several animal studies indicate that steviol may act as a vasodilator (36; 14).
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Stevia/Herb/Supplement Interactions:- Anti inflammatory herbsAnti inflammatory herbs: Based on animal study, stevia appears to have anti-inflammatory activity (38). The effects of concurrent use of anti-inflammatory agents and stevia are not clear.
- AntineoplasticsAntineoplastics: In an in vitro study, isosteviol, a constituent of stevia, prevented the growth of human cancer cells (32). The effects of concurrent use of antineoplastic agents and stevia are not clear.
- AntiviralsAntivirals: In vitro, hot water extracts from Stevia rebaudiana inhibited the replication of all four serotypes of human rotavirus (HRV) (11). The effects of concurrent use of antiviral agents and stevia are not clear.
- DiureticsDiuretics: Stevioside is secreted by renal tubular epithelia and induces diuresis and natriuresis (39).
- Fertility agentsFertility agents: Traditionally, stevia is used by women in Paraguay to control fertility (2). A study in rats indicated that chronic administration (60 days) of a Stevia rebaudiana aqueous extract may decrease male rat fertility (20). At a dose as high as 2.5g/kg in hamsters, stevioside did not have effects on growth and fertility of both sexes (25). The effects of concurrent use of fertility agents and stevia are not clear.
- HypoglycemicsHypoglycemics: Based on human (4; 17) and animal (4; 17) evidence , stevioside and aqueous extracts of Stevia rebaudiana leaves may decrease glucose levels. Rebaudioside A, a glycoside found in stevia, has been found to stimulate the production and activity of insulin (1).
- HypotensivesHypotensives: Stevioside (250-500mg) given thrice daily decreased systolic and diastolic blood pressure (14; 13; 15). Several animal studies support this observation (33).
- Vasodilator herbs and supplementsVasodilator herbs and supplements: Several animal studies indicate that steviol may act as a vasodilator (36; 41).
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Stevia/Food Interactions:- Insufficient available evidence.
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Stevia/Lab Interactions:- Blood pressureBlood pressure: Based on animal and human study, stevia may cause a decrease in blood pressure. After stevioside therapy, the systolic and diastolic blood pressure of hypertensive patients decreased (p<0.05) (14; 13). The hypotensive effect in spontaneously hypertensive rats lasted for more than 60 minutes with a dose of 200mg/kg (15). Several other animal studies support this observation (33).
- Glucose levelGlucose level: Based on human (4; 17) and animal (4; 17) evidence , stevioside and aqueous extracts of Stevia rebaudiana leaves may decrease glucose levels. Rebaudioside A, a glycoside found in stevia, has been found to stimulate the production and activity of insulin (1).
- Glucose tolerance testGlucose tolerance test: Based on human study in healthy volunteers, the extract of Stevia rebaudiana may increase glucose tolerance (17).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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